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產品與服務

產品名稱

APOE小鼠

所屬分類
沒有此類產品
產品描述

APOE
載脂蛋白Eapolipoprotein E,APOE)基因敲除小鼠,也可以稱其為APOE基因缺陷小鼠,是目前研究動脈粥樣硬化(AS)的經典模型,除此之外在糖尿病、神經退化性疾病和腎臟疾病等方面的研究中也發揮著重要作用。APOE在健康人體內的極低密度脂蛋白(VLDL)中發現,主要合成場所為肝臟,是一種能夠結合和轉運脂質的特殊蛋白,同時也參與著體內總膽固醇(TC)的逆向轉運,是一種多態性蛋白,可調節多種生物學功能,而其多態性與個體血脂水平和動脈粥樣硬化發生發展有密切聯系。APOE-/-小鼠模型的優點是在正常飼養條件下也可以產生復雜的血管病變,并且這些病變與人類AS病變具有可比性,發展過程類似于人類型高脂血癥,給予不同配方的高脂飲食可導致不同程度病理變化。5-6周齡APOE基因缺失小鼠在電鏡中可以觀察到大動脈內皮細胞表面有單核細胞粘附,并且血漿單核細胞向血管內皮遷移,隨著小鼠生長,大多數的APOE基因缺失小鼠會逐漸自發形成脂質條紋損傷,進一步發展可能會形成動脈瘤,老齡 APOE-/- 小鼠能模擬人不穩定斑塊的特點。APOE-/-小鼠在動脈粥樣硬化的自噬、凋亡、炎癥及剪切應力等方向的研究均具有重要作用。 

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