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產品與服務

產品名稱

LDLR小鼠

所屬分類
沒有此類產品
產品描述

LDLR
低密度脂蛋白受體(low density lipoprotein receptor, LDLR)是一種細胞膜表面的糖蛋白,廣泛分布于哺乳動物的腎上腺、肝、脂肪等組織細胞膜上,以肝細胞含量最多,通過介導血漿膽固醇的主要載體LDL進入細胞,調節細胞膽固醇水平和機體降脂作用,LDLR基因多態性與血脂紊亂、高血壓、心腦血管疾病的發生等密切相關。LDLR基因敲除小鼠(LDLR-/-)屬于常用的動脈粥樣硬化小鼠模型,可通過改變飼料中膽固醇含量控制血漿中膽固醇水平,使病變更接近人類病變,復雜病變發生需要高脂飼料誘導,形成動脈粥樣硬化高級階段喂養時間需要適當延長,LDLR-/-小鼠有較高的 IDL/LDL 水平,癥狀更接近于人的血脂紊亂癥。普通飲食飼養的LDLR-/-小鼠在生長過程當中主動脈弓處出現了輕微 AS 病變,西方飲食飼養的 LDLR-/-小鼠斑塊發展具有時間依賴性和部位選擇性的特點,LDLR-/-小鼠接受含膽酸的高脂飲食主動脈弓、胸主動脈、腹主動脈出現明顯的 AS 病變,隨著飼養時間的不斷增加主動脈根部炎癥細胞浸潤、巨噬細胞和膠原蛋白含量也明顯增多。LDLR-/-小鼠脂蛋白譜更接近于人類,能更好地模擬人體內脂蛋白的病理生理學改變。

 
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